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miR-21 coordinates tumor growth and modulates KRIT1 levels
miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 sil...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Academic Press
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3750217/ https://ncbi.nlm.nih.gov/pubmed/23872064 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.07.031 |
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