The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis

This study focuses on determining whether and how the novel PI3 kinase inhibitor NVP-BKM120 (BKM120) induces apoptosis and enhances TRAIL-induced apoptosis in human lung cancer cells. We found that BKM120 reduced Mcl-1 levels across the tested cell lines along with induction of apoptosis and enhance...

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Main Authors: Ren, Hui, Zhao, Liqun, Li, Yikun, Yue, Ping, Deng, Xingming, Owonikoko, Taofeek K., Chen, Mingwei, Khuri, Fadlo R., Sun, Shi-Yong
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750077/
https://ncbi.nlm.nih.gov/pubmed/23562472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.03.032
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