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Pyrimidine Base Damage Is Increased in Women with BRCA Mutations

Oxidatively-induced DNA damage was measured in the DNA of WBC from two groups of women: carriers of a BRCA mutation, but asymptomatic for disease, and healthy controls. Two oxidatively induced lesions were measured: a formamide remnant of pyrimidine base and the glycol modification of thymine. These...

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Detalhes bibliográficos
Main Authors: Budzinski, Edwin E., Patrzyc, Helen B., Dawidzik, Jean B., Freund, Harold G., Frederick, Peter, Godoy, Heidi E., Voian, Nicoleta C., Odunsi, Kunle, Box, Harold C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3750071/
https://ncbi.nlm.nih.gov/pubmed/23583677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.04.001
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