Functional human sperm capacitation requires both bicarbonate-dependent PKA activation and down-regulation of Ser/Thr phosphatases by Src family kinases

In all mammalian species studied so far, sperm capacitation correlates with an increase in protein tyrosine (Tyr) phosphorylation mediated by a bicarbonate-dependent cAMP/protein kinase A (PKA) pathway. Recent studies in mice revealed, however, that a Src family kinase (SFK)-induced inactivation of...

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Main Authors: Battistone, M.A., Da Ros, V.G., Salicioni, A.M., Navarrete, F.A., Krapf, D., Visconti, P.E., Cuasnicú, P.S.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749807/
https://ncbi.nlm.nih.gov/pubmed/23630234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gat033
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