Circulating Levels of IL-1B+IL-6 Cause ER Stress and Dysfunction in Islets From Prediabetic Male Mice

Elevated levels of circulating proinflammatory cytokines are associated with obesity and increased risk of type 2 diabetes, but the mechanism is unknown. We tested whether proinflammatory cytokines IL-1B+IL-6 at low picogram per milliliter concentrations (consistent with serum levels) could directly...

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Detalhes bibliográficos
Main Authors: O'Neill, Christina M., Lu, Christine, Corbin, Kathryn L., Sharma, Poonam R., Dula, Stacey B., Carter, Jeffrey D., Ramadan, James W., Xin, Wenjun, Lee, Jae K., Nunemaker, Craig S.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Diabetes-Insulin-Glucagon-Gastrointestinal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749476/
https://ncbi.nlm.nih.gov/pubmed/23836031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-2138
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