Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase–Dependent Manner in Diabetic Mice

Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose intolerance. Tetrahydrobiopterin (BH(4)) is an essential cofactor of eNOS that regulates eNOS activity. In the diabetic state, BH(4) is oxidized to 7,8-dihydrobiopterin, which leads to eNOS dysfunction owing...

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Detalhes bibliográficos
Main Authors: Abudukadier, Abulizi, Fujita, Yoshihito, Obara, Akio, Ohashi, Akiko, Fukushima, Toru, Sato, Yuichi, Ogura, Masahito, Nakamura, Yasuhiko, Fujimoto, Shimpei, Hosokawa, Masaya, Hasegawa, Hiroyuki, Inagaki, Nobuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749361/
https://ncbi.nlm.nih.gov/pubmed/23649519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1242
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