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Separation of Protein Conformers by Differential Ion Mobility in Hydrogen-Rich Gases

Proteins in solution or the gas phase tend to exhibit multiple conformational families, each comprising distinct structures. Separation methods have generally failed to resolve these, with their convolution producing wide peaks. Here we report full separation of >10 conformers for most ubiquitin...

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Detalhes bibliográficos
Main Authors: Shvartsburg, Alexandre A., Smith, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749073/
https://ncbi.nlm.nih.gov/pubmed/23855890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac4015963
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