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Separation of Protein Conformers by Differential Ion Mobility in Hydrogen-Rich Gases

Proteins in solution or the gas phase tend to exhibit multiple conformational families, each comprising distinct structures. Separation methods have generally failed to resolve these, with their convolution producing wide peaks. Here we report full separation of >10 conformers for most ubiquitin...

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Detalles Bibliográficos
Main Authors: Shvartsburg, Alexandre A., Smith, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3749073/
https://ncbi.nlm.nih.gov/pubmed/23855890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac4015963
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