MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells

BACKGROUND: The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action is mediated by 2 protein complexes, PRC1 and PRC2. PRC is oncogenic in glioblastoma, where it is involved in cancer stem cell maintenance and radioresistance. METHODS: We used a set of glioblast...

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Hlavní autoři: Peruzzi, Pierpaolo, Bronisz, Agnieszka, Nowicki, Michal O., Wang, Yan, Ogawa, Daisuke, Price, Richard, Nakano, Ichiro, Kwon, Chang-Hyuk, Hayes, Josie, Lawler, Sean E., Ostrowski, Michael C., Chiocca, E. Antonio, Godlewski, Jakub
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748913/
https://ncbi.nlm.nih.gov/pubmed/23733246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not055
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