Delivery system for DNAzymes using arginine-modified hydroxyapatite nanoparticles for therapeutic application in a nasopharyngeal carcinoma model

DNAzymes are synthetic, single-stranded, catalytic nucleic acids that bind and cleave target mRNA in a sequence-specific manner, and have been explored for genotherapeutics. One bottleneck restricting their application is the lack of an efficient delivery system. As an inorganic nanomaterial with po...

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Detalhes bibliográficos
Main Authors: Chen, Yan, Yang, Lifang, Huang, Suping, Li, Zhi, Zhang, Lu, He, Jiang, Xu, Zhijie, Liu, Liyu, Cao, Ya, Sun, Lunquan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2013
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747848/
https://ncbi.nlm.nih.gov/pubmed/23983464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S48321
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