A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K(2P) Channels

[Image: see text] K(2P) (KCNK) potassium channels generate “leak” potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiological importance, K(2P)s lack specific pharmacology. Addressing this issue has been...

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Main Authors: Bagriantsev, Sviatoslav N., Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A., Arkin, Michelle R., Renslo, Adam R., Minor, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747594/
https://ncbi.nlm.nih.gov/pubmed/23738709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400289x
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