Role of the Plasma Membrane Transporter of Organic Cations OCT1 and Its Genetic Variants in Modern Liver Pharmacology

Changes in the uptake of many drugs by the target cells may dramatically affect the pharmacological response. Thus, downregulation of SLC22A1, which encodes the organic cation transporter type 1 (OCT1), may affect the response of healthy hepatocytes and liver cancer cells to cationic drugs, such as...

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Detalhes bibliográficos
Main Authors: Lozano, Elisa, Herraez, Elisa, Briz, Oscar, Robledo, Virginia S., Hernandez-Iglesias, Jorge, Gonzalez-Hernandez, Ana, Marin, Jose J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
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Review Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747481/
https://ncbi.nlm.nih.gov/pubmed/23984399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/692071
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