Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A

Anaphase central spindle formation is controlled by the microtubule-stabilizing factor PRC1 and the kinesin KIF4A. We show that an MKlp2-dependent pool of Aurora B at the central spindle, rather than global Aurora B activity, regulates KIF4A accumulation at the central spindle. KIF4A phosphorylation...

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Detaylı Bibliyografya
Asıl Yazarlar: Nunes Bastos, Ricardo, Gandhi, Sapan R., Baron, Ryan D., Gruneberg, Ulrike, Nigg, Erich A., Barr, Francis A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2013
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747307/
https://ncbi.nlm.nih.gov/pubmed/23940115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201301094
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