Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers

BACKGROUND: Interaction of transmembrane mucins with the multivalent carbohydrate-binding protein galectin-3 is critical to maintaining the integrity of the ocular surface epithelial glycocalyx. This study aimed to determine whether disruption of galectin-3 multimerization and insertion of synthetic...

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Detalhes bibliográficos
Main Authors: Mauris, Jerome, Mantelli, Flavio, Woodward, Ashley M., Cao, Ziyhi, Bertozzi, Carolyn R., Panjwani, Noorjahan, Godula, Kamil, Argüeso, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747151/
https://ncbi.nlm.nih.gov/pubmed/23977277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072304
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