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Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis

Infection by pathogenic fungi, such as Candida albicans, begins with adhesion to host cells or implanted medical devices followed by biofilm formation. By high-throughput phenotypic screening of small molecules, we identified compounds that inhibit adhesion of C. albicans to polystyrene. Our lead ca...

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Bibliografiske detaljer
Main Authors: Fazly, Ahmed, Jain, Charu, Dehner, Amie C., Issi, Luca, Lilly, Elizabeth A., Ali, Akbar, Cao, Hong, Fidel, Paul L., P. Rao, Reeta, Kaufman, Paul D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746938/
https://ncbi.nlm.nih.gov/pubmed/23904484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305982110
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