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Competition by Inhibitory Oligonucleotides Prevents Binding of CpG to C-terminal TLR9
TLR9 recognizes unmethylated CpG-containing DNA commonly found in bacteria. Synthetic oligonucleotides containing CpG-motifs (CpG ODNs) recapitulate the activation of TLR9 by microbial DNA, whereas inversion of the CG dinucleotide within the CpG motif to GC (GpC ODN) renders such ODNs inactive. This...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746339/ https://ncbi.nlm.nih.gov/pubmed/21766476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201141563 |
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