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Resistance to EGFR-TKI can be mediated through multiple signaling pathways converging upon cap-dependent translation in EGFR-wild type NSCLC
INTRODUCTION: For the majority of patients with non-small cell lung cancer, response to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) is suboptimal. In models of acquired resistance to EGFR-TKI, activation of Akt phosphorylation is frequently observed. Since Akt activation r...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3745544/ https://ncbi.nlm.nih.gov/pubmed/23883783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31829ce963 |
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