Trimeric Tn Antigen on Syndecan 1 Produced by ppGalNAc-T13 Enhances Cancer Metastasis via a Complex Formation with Integrin α5β1 and Matrix Metalloproteinase 9

We demonstrated previously that ppGalNAc-T13 (T13), identified as an up-regulated gene with increased metastasis in a DNA microarray, generated trimeric Tn (tTn) antigen (GalNAcα1-Ser/Thr)(3) on Syndecan 1 in highly metastatic sublines of Lewis lung cancer. However, it is not known how tTn antigen r...

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Detalhes bibliográficos
Main Authors: Matsumoto, Yasuyuki, Zhang, Qing, Akita, Kaoru, Nakada, Hiroshi, Hamamura, Kazunori, Tsuchida, Akiko, Okajima, Tetsuya, Furukawa, Keiko, Urano, Takeshi, Furukawa, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745370/
https://ncbi.nlm.nih.gov/pubmed/23814067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.455006
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