Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor–induced interleukin 12 synthesis

Src-kinase inhibitors hold great potential as targeted therapy against malignant cells. However, such inhibitors may also affect nonmalignant cells and cause pronounced off-target effects. We investigated the role of the dual kinase inhibitor dasatinib on human myeloid cells. Dasatinib is clinically...

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Autores principales: Wölfl, Matthias, Schwinn, Stefanie, Yoo, Young-Eun, Reß, Marie L., Braun, Matthias, Chopra, Martin, Schreiber, Susanne C., Ayala, Victor I., Ohlen, Claes, Eyrich, Matthias, Beilhack, Andreas, Schlegel, Paul G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2013
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744989/
https://ncbi.nlm.nih.gov/pubmed/23836556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-488072
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