Screening of Dihydropyrimidine Dehydrogenase Genetic Variants by Direct Sequencing in Different Ethnic Groups

Dihydropyrimidine dehydrogenase (DPYD) is an enzyme that regulates the rate-limiting step in pyrimidine metabolism, especially catabolism of fluorouracil, a chemotherapeutic agent for cancer. In order to determine the genetic distribution of DPYD, we directly sequenced 288 subjects from five ethnic...

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Detalhes bibliográficos
Main Authors: Shin, Joong-Gon, Cheong, Hyun Sub, Kim, Jason Yongha, Kim, Lyoung Hyo, Han, Chang Soo, Kim, Ji On, Kim, Hae Deun, Kim, Young Hoon, Chung, Myeon Woo, Han, Soon Young, Shin, Hyoung Doo
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Academy of Medical Sciences 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744698/
https://ncbi.nlm.nih.gov/pubmed/23960437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3346/jkms.2013.28.8.1129
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