Local CD4 and CD8 T-Cell Reactivity to HSV-1 Antigens Documents Broad Viral Protein Expression and Immune Competence in Latently Infected Human Trigeminal Ganglia

Herpes simplex virus type 1 (HSV-1) infection results in lifelong chronic infection of trigeminal ganglion (TG) neurons, also referred to as neuronal HSV-1 latency, with periodic reactivation leading to recrudescent herpetic disease in some persons. HSV-1 proteins are expressed in a temporally coord...

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Autores principales: van Velzen, Monique, Jing, Lichen, Osterhaus, Albert D. M. E., Sette, Alessandro, Koelle, David M., Verjans, Georges M. G. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744444/
https://ncbi.nlm.nih.gov/pubmed/23966859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003547
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