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Preclinical evaluation of the mTOR inhibitor, temsirolimus, in combination with the epothilone B analog, ixabepilone in renal cell carcinoma

Historically, metastatic renal cell carcinoma (mRCC) is more resistant to conventional cytotoxic chemotherapeutic agents than other solid tumors. Although significant progress has been made over the last decade with several novel therapeutics, these agents invariably go on to fail, largely due to ei...

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Autori principali: von Roemeling, Christina A, Marlow, Laura A, Kennedy, William P, Kennedy, Gregory T, Copland, John A, Menefee, Michael E
Natura: Artigo
Lingua:Inglês
Pubblicazione: e-Century Publishing Corporation 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744018/
https://ncbi.nlm.nih.gov/pubmed/23977448
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