Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Is Pyruvylated during 3-Bromopyruvate Mediated Cancer Cell Death

BACKGROUND: The pyruvic acid analog 3-bromopyruvate (3BrPA) is an alkylating agent known to induce cancer cell death by blocking glycolysis. The anti-glycolytic effect of 3BrPA is considered to be the inactivation of glycolytic enzymes. Yet, there is a lack of experimental documentation on the direc...

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Main Authors: Ganapathy-Kanniappan, Shanmugasundaram, Geschwind, Jean-Francois H., Kunjithapatham, Rani, Buijs, Manon, Vossen, Josephina A., Tchernyshyov, Irina, Cole, Robert N., Syed, Labiq H., Rao, Pramod P., Ota, Shinichi, Vali, Mustafa
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743725/
https://ncbi.nlm.nih.gov/pubmed/20044597
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