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Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

The aggregation of the 42-residue amyloid β-protein (Aβ42) is involved in the pathogenesis of Alzheimer disease (AD). Numerous flavonoids exhibit inhibitory activity against Aβ42 aggregation, but their mechanism remains unclear in the molecular level. Here we propose the site-specific inhibitory mec...

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Bibliografiske detaljer
Main Authors: Sato, Mizuho, Murakami, Kazuma, Uno, Mayumi, Nakagawa, Yu, Katayama, Sumie, Akagi, Ken-ichi, Masuda, Yuichi, Takegoshi, Kiyonori, Irie, Kazuhiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743493/
https://ncbi.nlm.nih.gov/pubmed/23792961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464222
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