Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

The aggregation of the 42-residue amyloid β-protein (Aβ42) is involved in the pathogenesis of Alzheimer disease (AD). Numerous flavonoids exhibit inhibitory activity against Aβ42 aggregation, but their mechanism remains unclear in the molecular level. Here we propose the site-specific inhibitory mec...

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Detalhes bibliográficos
Main Authors: Sato, Mizuho, Murakami, Kazuma, Uno, Mayumi, Nakagawa, Yu, Katayama, Sumie, Akagi, Ken-ichi, Masuda, Yuichi, Takegoshi, Kiyonori, Irie, Kazuhiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743493/
https://ncbi.nlm.nih.gov/pubmed/23792961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464222
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