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Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China
Obstacles to developing an HIV-1 vaccine include extensive viral diversity and lack of correlates of protective immunity. High mutation rates allow HIV-1 to adapt rapidly to selective forces such as antiretroviral therapy and immune pressure, including HIV-1–specific CTLs that select viral variants...
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Main Authors: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society of Hematology
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743462/ https://ncbi.nlm.nih.gov/pubmed/21562042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-06-291963 |
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