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Leflunomide Reduces Proliferation and Induces Apoptosis in Neuroblastoma Cells In Vitro and In Vivo

Leflunomide as an immunosuppressive drug is generally used in the treatment of rheumatoid arthritis. It inhibits DHODH (dihydroorotate dehydrogenase ), which is one of the essential enzymes in the de novo pyrimidine biosynthetic pathway. Here we showed that leflunomide significantly reduced cell pro...

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Autores principales: Zhu, Shunqin, Yan, Xiaomin, Xiang, Zhonghuai, Ding, Han-Fei, Cui, Hongjuan
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743402/
https://ncbi.nlm.nih.gov/pubmed/23977077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071555
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