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Targeted inhibition of TGF-β results in an initial improvement but long-term deficit in force production after contraction-induced skeletal muscle injury

Transforming growth factor-β (TGF-β) is a proinflammatory cytokine that regulates the response of many tissues following injury. Previous studies in our lab have shown that treating muscles with TGF-β results in a dramatic accumulation of type I collagen, substantial fiber atrophy, and a marked decr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gumucio, Jonathan P., Flood, Michael D., Phan, Anthony C., Brooks, Susan V., Mendias, Christopher L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742948/
https://ncbi.nlm.nih.gov/pubmed/23766498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.00374.2013
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