Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis

In catabolic conditions such as aging and diabetes, IGF signaling is impaired and fibrosis develops in skeletal muscles. To examine whether impaired IGF signaling initiates muscle fibrosis, we generated IGF-IR(+/−) heterozygous mice by crossing loxP-floxed IGF-IR (exon 3) mice with MyoD-cre mice. IG...

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Bibliografische gegevens
Hoofdauteurs: Dong, Yanjun, Lakhia, Ronak, Thomas, Sandhya S., Dong, Yanlan, Wang, Xiaonan H., Silva, Kleiton Augusto Santos, Zhang, Liping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2013
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742853/
https://ncbi.nlm.nih.gov/pubmed/23736539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00644.2012
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