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Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis
In catabolic conditions such as aging and diabetes, IGF signaling is impaired and fibrosis develops in skeletal muscles. To examine whether impaired IGF signaling initiates muscle fibrosis, we generated IGF-IR(+/−) heterozygous mice by crossing loxP-floxed IGF-IR (exon 3) mice with MyoD-cre mice. IG...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742853/ https://ncbi.nlm.nih.gov/pubmed/23736539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00644.2012 |
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