Interactions between p-Akt and Smad3 in injured muscles initiate myogenesis or fibrogenesis

In catabolic conditions such as aging and diabetes, IGF signaling is impaired and fibrosis develops in skeletal muscles. To examine whether impaired IGF signaling initiates muscle fibrosis, we generated IGF-IR(+/−) heterozygous mice by crossing loxP-floxed IGF-IR (exon 3) mice with MyoD-cre mice. IG...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dong, Yanjun, Lakhia, Ronak, Thomas, Sandhya S., Dong, Yanlan, Wang, Xiaonan H., Silva, Kleiton Augusto Santos, Zhang, Liping
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2013
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742853/
https://ncbi.nlm.nih.gov/pubmed/23736539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00644.2012
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