Suppression of the Induction of Alpha, Beta, and Gamma Interferons by the NS1 and NS2 Proteins of Human Respiratory Syncytial Virus in Human Epithelial Cells and Macrophages

Wild-type human respiratory syncytial virus (HRSV) is a poor inducer of alpha/beta interferons (IFN-α/β). However, recombinant HRSV lacking the NS1 and NS2 genes (ΔNS1/2) induced high levels of IFN-α and -β in human pulmonary epithelial cells (A549) as well as in macrophages derived from primary hum...

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Bibliographische Detailangaben
Hauptverfasser: Spann, Kirsten M., Tran, Kim-C., Chi, Bo, Rabin, Ronald L., Collins, Peter L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Virus-Cell Interactions
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC374276/
https://ncbi.nlm.nih.gov/pubmed/15047850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4363-4369.2004
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