Selective Modification of Variable Loops Alters Tropism and Enhances Immunogenicity of Human Immunodeficiency Virus Type 1 Envelope

Although the B clade of human immunodeficiency virus type 1 (HIV-1) envelopes (Env) includes five highly variable regions, each of these domains contains a subset of sequences that remain conserved. The V3 loop has been much studied for its ability to elicit neutralizing antibodies, which are often...

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Autori principali: Yang, Zhi-yong, Chakrabarti, Bimal K., Xu, Ling, Welcher, Brent, Kong, Wing-pui, Leung, Kwanyee, Panet, Amos, Mascola, John R., Nabel, Gary J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2004
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC374252/
https://ncbi.nlm.nih.gov/pubmed/15047819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.8.4029-4036.2004
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