Reduced Juvenile Long-Term Depression in Tuberous Sclerosis Complex Is Mitigated in Adults by Compensatory Recruitment of mGluR5 and Erk Signaling

Tuberous sclerosis complex (TSC) is a multisystem genetic disease that manifests with mental retardation, tumor formation, autism, and epilepsy. Heightened signaling through the mammalian target of rapamycin (mTOR) pathway is involved in TSC pathology, however it remains unclear how other signaling...

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Main Authors: Potter, Wyatt B., Basu, Trina, O'Riordan, Kenneth J., Kirchner, Allison, Rutecki, Paul, Burger, Corinna, Roopra, Avtar
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742461/
https://ncbi.nlm.nih.gov/pubmed/23966835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001627
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