Accelerated Evolution of the ASPM Gene Controlling Brain Size Begins Prior to Human Brain Expansion

Primary microcephaly (MCPH) is a neurodevelopmental disorder characterized by global reduction in cerebral cortical volume. The microcephalic brain has a volume comparable to that of early hominids, raising the possibility that some MCPH genes may have been evolutionary targets in the expansion of t...

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Main Authors: Kouprina, Natalay, Pavlicek, Adam, Mochida, Ganeshwaran H, Solomon, Gregory, Gersch, William, Yoon, Young-Ho, Collura, Randall, Ruvolo, Maryellen, Barrett, J. Carl, Woods, C. Geoffrey, Walsh, Christopher A, Jurka, Jerzy, Larionov, Vladimir
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC374243/
https://ncbi.nlm.nih.gov/pubmed/15045028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020126
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