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Topological challenges to DNA replication: Conformations at the fork

The unwinding of the parental DNA duplex during replication causes a positive linking number difference, or superhelical strain, to build up around the elongating replication fork. The branching at the fork and this strain bring about different conformations from that of (−) supercoiled DNA that is...

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Autori principali: Postow, Lisa, Crisona, Nancy J., Peter, Brian J., Hardy, Christine D., Cozzarelli, Nicholas R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC37424/
https://ncbi.nlm.nih.gov/pubmed/11459956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.111006998
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