A Conserved Role for Atlastin GTPases in Regulating Lipid Droplet Size

Lipid droplets (LDs) are the major fat storage organelles in eukaryotic cells, but how their size is regulated is unknown. Using genetic screens in C. elegans for LD morphology defects in intestinal cells, we found that mutations in atlastin, a GTPase required for homotypic fusion of endoplasmic ret...

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Detalhes bibliográficos
Main Authors: Klemm, Robin W., Norton, Justin P., Cole, Ronald A., Li, Chen S., Park, Seong H., Crane, Matthew M., Li, Liying, Jin, Diana, Boye-Doe, Alexandra, Liu, Tina Y., Shibata, Yoko, Lu, Hang, Rapoport, Tom A., Farese, Robert V., Blackstone, Craig, Guo, Yi, Mak, Ho Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742324/
https://ncbi.nlm.nih.gov/pubmed/23684613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.015
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