Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis

Enhancement of hematopoietic recovery after radiation, chemotherapy, or hematopoietic stem cell (HSC) transplantation is clinically relevant. Dipeptidylpeptidase (DPP4) cleaves a wide variety of substrates, including the chemokine stromal cell-derived factor-1 (SDF-1). In the course of experiments s...

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Bibliographic Details
Main Authors:	Broxmeyer, Hal E, Hoggatt, Jonathan, O’Leary, Heather A, Mantel, Charlie, Chitteti, Brahmananda R, Cooper, Scott, Messina-Graham, Steven, Hangoc, Giao, Farag, Sherif, Rohrabaugh, Sara L, Ou, Xuan, Speth, Jennifer, Pelus, Louis M, Srour, Edward F, Campbell, Timothy B
Format:	Artigo
Language:	Inglês
Published:	2012
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3742313/ https://ncbi.nlm.nih.gov/pubmed/23160239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2991
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Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis

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