Delta-Sarcoglycan Gene Therapy Halts Progression of Cardiac Dysfunction, Improves Respiratory Failure and Prolongs Life in Myopathic Hamsters

BACKGROUND: The BIO14.6 hamster provides a useful model of hereditary cardiomyopathies and muscular dystrophy. Previous delta-sarcoglycan (δSG) gene therapy (GT) studies were limited to neonatal and young adult animals, and prevented the development of cardiac and skeletal muscle dysfunction. GT of...

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Main Authors: Hoshijima, Masahiko, Hayashi, Takeharu, Jeon, Young E., Fu, Zhenxing, Gu, Yusu, Dalton, Nancy D., Ellisman, Mark H., Xiao, Xiao, Powell, Frank L., Ross, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742303/
https://ncbi.nlm.nih.gov/pubmed/21036890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.110.957258
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