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Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
Mutations in bone morphogenetic protein receptor type 2 (BMPR2) cause familial pulmonary arterial hypertension (FPAH), but the penetrance is reduced and females are significantly overrepresented. In addition, gene expression data implicating the oestrogen-metabolising enzyme CYP1B1 suggests a detrim...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742124/ https://ncbi.nlm.nih.gov/pubmed/19357154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/09031936.00010409 |
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