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454 next generation-sequencing outperforms allele-specific PCR, Sanger sequencing, and pyrosequencing for routine KRAS mutation analysis of formalin-fixed, paraffin-embedded samples

Detection of KRAS mutations in archival pathology samples is critical for therapeutic appropriateness of anti-EGFR monoclonal antibodies in colorectal cancer. We compared the sensitivity, specificity, and accuracy of Sanger sequencing, ARMS-Scorpion (TheraScreen®) real-time polymerase chain reaction...

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Hlavní autoři:	Altimari, Annalisa, de Biase, Dario, De Maglio, Giovanna, Gruppioni, Elisa, Capizzi, Elisa, Degiovanni, Alessio, D’Errico, Antonia, Pession, Annalisa, Pizzolitto, Stefano, Fiorentino, Michelangelo, Tallini, Giovanni
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Dove Medical Press 2013
Témata:	Original Research
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3741083/ https://ncbi.nlm.nih.gov/pubmed/23950653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S42369
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454 next generation-sequencing outperforms allele-specific PCR, Sanger sequencing, and pyrosequencing for routine KRAS mutation analysis of formalin-fixed, paraffin-embedded samples

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