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Optimal Continuous-Monitoring Design of Single-arm Phase II Trial Based on the Simulated Annealing Method
Simon’s two-stage design is commonly used in phase II single-arm clinical trials because of its simplicity and smaller sample size under the null hypothesis compared to the one-stage design. Some studies extend this design to accommodate more interim analyses (i.e., three-stage or four-stage designs...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3741066/ https://ncbi.nlm.nih.gov/pubmed/23545075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2013.03.006 |
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