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Optimal Continuous-Monitoring Design of Single-arm Phase II Trial Based on the Simulated Annealing Method

Simon’s two-stage design is commonly used in phase II single-arm clinical trials because of its simplicity and smaller sample size under the null hypothesis compared to the one-stage design. Some studies extend this design to accommodate more interim analyses (i.e., three-stage or four-stage designs...

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書目詳細資料
Main Authors: Chen, Nan, Lee, J. Jack
格式: Artigo
語言:Inglês
出版: 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741066/
https://ncbi.nlm.nih.gov/pubmed/23545075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cct.2013.03.006
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