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Accelerated decline in lung function in cigarette smokers is associated with TP53/HDM2 polymorphisms

In vitro studies have shown that p53 mediates a protective response against DNA damage by causing either cell-cycle arrest and DNA repair, or apoptosis. These responses have not yet been demonstrated in humans. A common source of DNA damage in humans is cigarette smoke, which should activate p53 rep...

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Main Authors: Hancox, Robert J, Poulton, Richie, Welch, David, Olova, Nelly, McLachlan, Christene R, Greene, Justina M, Sears, Malcolm R, Caspi, Avshalom, Moffitt, Terrie E., Robertson, Stephen P., Braithwaite, Antony W.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740961/
https://ncbi.nlm.nih.gov/pubmed/19521721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-009-0704-z
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