Activation of p53 with Nutlin-3a radiosensitizes lung cancer cells via enhancing radiation-induced premature senescence

Radiotherapy is routinely used for the treatment of lung cancer. However, the mechanisms underlying ionizing radiation (IR)-induced senescence and its role in lung cancer treatment are poorly understood. Here, we show that IR suppresses the proliferation of human non-small cell lung cancer (NSCLC) c...

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Главные авторы: Luo, Hongmei, Yount, Caroline, Lang, Hainan, Yang, Aimin, Riemer, Ellen C., Lyons, Katherine, Vanek, Kenneth N., Silvestri, Gerard A., Schulte, Bradley A., Wang, Gavin Y.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739976/
https://ncbi.nlm.nih.gov/pubmed/23683497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2013.04.017
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