Phase I Pharmacokinetic and Pharmacodynamic Study of Pazopanib in Children With Soft Tissue Sarcoma and Other Refractory Solid Tumors: A Children's Oncology Group Phase I Consortium Report

PURPOSE: Pazopanib, an oral multikinase angiogenesis inhibitor, prolongs progression-free survival in adults with soft tissue sarcoma (STS). A phase I pharmacokinetic and pharmacodynamic study of two formulations of pazopanib was performed in children with STS or other refractory solid tumors. PATIE...

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Main Authors: Glade Bender, Julia L., Lee, Alice, Reid, Joel M., Baruchel, Sylvain, Roberts, Timothy, Voss, Stephan D., Wu, Bing, Ahern, Charlotte H., Ingle, Ashish M., Harris, Pamela, Weigel, Brenda J., Blaney, Susan M.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2013
Teme:
Original Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739862/
https://ncbi.nlm.nih.gov/pubmed/23857966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2012.47.0914
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