Structural Guided Scaffold Phage Display Libraries as a Source of Bio-Therapeutics

We have developed a structurally-guided scaffold phage display strategy for identification of ligand mimetic bio-therapeutics. As a proof of concept we used the ligand of integrin αvβ6, a tumour cell surface receptor and a major new target for imaging and therapy of many types of solid cancer. NMR s...

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Bibliographic Details
Main Authors: Man, Y. K. Stella, DiCara, Danielle, Chan, Nicole, Vessillier, Sandrine, Mather, Stephen J., Rowe, Michelle L., Howard, Mark J., Marshall, John F., Nissim, Ahuva
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739823/
https://ncbi.nlm.nih.gov/pubmed/23950939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070452
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