Hypomethylation of Noncoding DNA Regions and Overexpression of the Long Noncoding RNA, AFAP1-AS1, in Barrett’s Esophagus and Esophageal Adenocarcinoma

BACKGROUND & AIMS: Alterations in methylation of protein-coding genes are associated with Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). Dys-regulation of noncoding RNAs occurs during carcinogen-esis but has never been studied in BE or EAC. We applied high-resolution methylome ana...

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主要な著者: Wu, Wenjing, Bhagat, Tushar D., Yang, Xue, Song, Jee Hoon, Cheng, Yulan, Agarwal, Rachana, Abraham, John M., Ibrahim, Sariat, Bartenstein, Matthias, Hussain, Zulfiqar, Suzuki, Masako, Yu, Yiting, Chen, Wei, Eng, Charis, Greally, John, Verma, Amit, Meltzer, Stephen J.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739703/
https://ncbi.nlm.nih.gov/pubmed/23333711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2013.01.019
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