Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro

Limited treatment options are available for aggressive prostate cancer. Gossypol has been reported to have a potent anticancer activity in many types of cancer. It can increase the sensitivity of cancer cells to alkylating agents, diminish multidrug resistance and decrease metastasis. Whether or not...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Xian-Qing, Huang, Xiao-Feng, Hu, Xing-Bin, Zhan, Yong-Hua, An, Qun-Xing, Yang, Shi-Ming, Xia, Ai-Jun, Yi, Jing, Chen, Rui, Mu, Shi-Jie, Wu, Dao-Cheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2010
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739319/
https://ncbi.nlm.nih.gov/pubmed/20657602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aja.2010.57
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