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Lentivirus-mediated SMO RNA interference inhibits SMO expression and cell proliferation, and affects the cell cycle in LNCaP and PC3 cancer cell lines

Smoothened (SMO) is an important member of the Hedgehog signaling pathway. We constructed a specific recombinant lentiviral vector for RNA interference, targeting the SMO gene (NM_005631) to observe its effect on SMO expression, cell proliferation and the cell cycle in the human androgen-sensitive p...

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Detalhes bibliográficos
Main Authors: Yang, Bo, Sun, Heng-Yun, Chen, Wei-Hua, Wen, Ji-Ling, Shi, Xiang-Ting, Wang, Yue-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3739093/
https://ncbi.nlm.nih.gov/pubmed/20023691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aja.2009.79
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