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Opening of the MitoK(ATP) Channel and Decoupling of Mitochondrial Complex II and III Contribute to the Suppression of Myocardial Reperfusion Hyperoxygenation

Diazoxide, a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel opener, protects the heart from ischemia-reperfusion injury. Diazoxide also inhibits mitochondrial complex II-dependent respiration in addition to its preconditioning effect. However, there are no prior studies of the role of di...

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Autors principals: Liu, Bin, Zhu, Xuehai, Chen, Chwen-Lih, Hu, Keli, Harold M, Swartz, Chen, Yeong-Renn, He, Guanglong
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738814/
https://ncbi.nlm.nih.gov/pubmed/19851835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11010-009-0283-2
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