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Antagonism of the prostaglandin E receptor EP4 inhibits metastasis and enhances NK function
Cyclooxygenase-2 (COX-2) is associated with aggressive breast cancers. The COX-2 product prostaglandin E2 (PGE2) acts through four G-protein-coupled receptors designated EP1–4. Malignant and immortalized normal mammary epithelial cell lines express all four EP. The EP4 antagonist AH23848 reduced the...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3738188/ https://ncbi.nlm.nih.gov/pubmed/18792778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-008-0180-5 |
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