Small Molecule Inhibition of p38 MAP Kinase Extends the Replicative Life Span of Human ATR-Seckel Syndrome Fibroblasts

Ataxia-telangiectasia and rad3 (ATR)-related Seckel syndrome is associated with growth retardation and premature aging features. ATR-Seckel fibroblasts have a reduced replicative capacity in vitro and an aged morphology that is associated with activation of stress-associated p38 mitogen-activated pr...

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Main Authors: Tivey, Hannah S. E., Rokicki, Michal J., Barnacle, James R., Rogers, Matthew J., Bagley, Mark C., Kipling, David, Davis, Terence
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3738025/
https://ncbi.nlm.nih.gov/pubmed/23401567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gls336
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